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March 23-24, 2018

New York, New York

Scientific Agenda

Scientific Topics


Colorectal Cancers

  • What is the optimal therapy for a BRAF mutant metastatic colorectal cancer?
  • For left sided RAS wild type metastatic colon cancers first line EGFR therapy is mandatory.
    • Yes vs. no
  • Is there an optimal salvage therapy for refractory colon cancer?
    • Optimal salvage therapy for refractory colon cancer is TAS102 or regorafenib
    • Optimal salvage therapy is cobimetinib + atezolizumab
  • Molecular subsets in colorectal cancer/impact on adjuvant and advanced disease therapy
  • What is the duration of therapy for low risk stage III colon cancer?
    • Adjuvant therapy for low risk stage III colon cancer: should be 3 months of therapy
    • 6 months remains the standard of care for low risk stage III colon cancer
  • What is the duration of therapy for high risk stage III colon cancer?
    • 3 months of Cape-Ox is acceptable
    • 6 months of chemotherapy remains standard
  • Do molecular characteristics play a role in selecting patients for metastectomy?
    • Molecular characteristics including RAS and BRAF mutation status should determine role of metastatectomy
    • Molecular characteristics should not play a role in selecting patients for metastectomy

Immunotherapy

  • Do we have reliable biomarkers to guide use of immunotherapy agents?
  • What is the status of combination and novel immunotherapy approaches in GI cancers?

Gastrointestinal Malignancies – Emerging Concepts & Therapies

  • What is the status of Ytrium microsphere therapy in hepatic metastases in GI cancers?
  • What is the status of use of liquid biopsies in oncologic practice?
  • Familial cancer syndromes in GI cancers – Who should be tested and why?

Rare Tumors

  • Update in the treatment of GIST
  • Treatment update of neuroendocrine cancers
  • Is there a role for radiation therapy in the management of rectal cancer?
    • Induction chemotherapy with selective application of radiation therapy for rectal cancer is preferred
    • Combination chemotherapy and radiation therapy for rectal cancer is preferred

Upper GI Cancers

  • Update on novel radiotherapy approaches in GI cancers
  • Routine genomic profiling should be performed in esophagogastric cancer? 
    • Yes vs. no
  • What is the optimal therapy for GEJ cancers?
    • FLOT is the optimal therapy
    • CROSS is the optimal therapy

Pancreatic Cancer

  • What is the optimal neoadjuvant strategy in pancreatic cancer? 
    • Chemotherapy alone
    • Pre-operative chemotherapy plus radiation
  • What is the optimal therapy for borderline resectable pancreatic cancer?
    • Optimal therapy for borderline resectable pancreatic cancer is FOLFIRINOX
    • Optimal therapy for borderline resectable pancreatic cancer is chemo + SBRT
  • What is new in treatment for pancreatic adenocarcinoma? 

Hepatobiliary Cancers

  • Endoscopic management approaches to hepatobiliary cancers
  • What is optimal adjuvant therapy of biliary cancer?
    • Optimal adjuvant therapy of biliary cancer is capecitabine/gemcitabine
    • Optimal adjuvant therapy of biliary cancer is chemotherapy + radiotherapy
  • What is the optimal strategy for resection in HCC
    • Resecting liver confined disease is optimal
    • Resecting extra hepatic metastases is optimal