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Targeted Audience
This educational activity is specifically designed for hematologists, oncologists, internists and other physicians, physicians-in-training, and healthcare professionals (nurses, pharmacists) involved in and/or interested in lymphoma related plasma cell disorders and their management.

Overview
This Webcast is taken from the live symposium held at the October 2007 Lymphoma and Myeloma meeting in New York, New York. The thought-provoking discussions pertaining to anti-CD20 therapy in B-cell lymphoma include a review of the mechanisms of action, strengths, and weaknesses of currently approved agents, as well as a description of novel anti-CD20 therapies in the testing phase. The chairman of the meeting, Dr John Leonard, is also the moderator.

Objectives
After viewing this activity, the participant will be able to:

1. Describe the biology of anti-CD20 antibodies and their mechanisms of action and resistance
2. Examine and compare the benefits of the current standard therapies available for CD20-positive
   B-cell lymphomas
3. Summarize and discuss the emerging anti-CD20 antibodies for B-cell lymphoma

Disclosure Statement
As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), Imedex^®, LLC must ensure balance, objectivity, independence, and scientific rigor in its educational activities. Faculty are encouraged to provide a balanced view of therapeutic options by utilizing generic names of several to ensure impartiality.

All faculty participating in an Imedex activity are required to disclose commitments to and/or relationships with pharmaceutical companies, biomedical device manufacturers or distributors, or others whose products or services may be considered to be related to the subject matter of the educational activity. Disclosure of these commitments and/or relationships is included in these course materials so that participants in the activity may formulate their own judgments in interpreting its content and evaluating its recommendations.

The following indicates the faculty disclosure declaration information and the nature of those commercial relationships.

1=grant/research support  2=consultant  3=speaker’s bureau  4=stock shareholder  5=other support

The following speakers have reported an affiliation with the supporters of this conference:

The following speakers do not report any affiliation:

All materials are included with the permission of the authors.

All Imedex staff members who are in a position to control the content of this activity have no financial relationships with any commercial interests that are relevant to this activity.

Sponsorship Statement
This activity is sponsored by Imedex, LLC.

Accreditation Statement
Imedex, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Imedex, LLC designates this educational activity for a maximum of 1.00 AMA PRA Category 1 Credits^™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

In order to receive credit, participants must successfully complete the post-test and complete the online evaluation form. You will receive an online CME statement of credit to print for your records.

For questions regarding the accreditation of this activity, please contact

Unapproved and Investigational Uses of Drug and Devices
This Webcast may contain information about experimental and other uses of drugs or devices that are not currently approved by the US Food and Drug Administration (FDA) and/or other national regulatory agencies in the United States and other countries. Participants in the United States are encouraged to consult the FDA-approved product labeling for any drug or device mentioned in this program before use. Participants from other countries should consult with their respective regulatory authorities.

Support
The following company has provided an unrestricted educational grant in support of this activity: GlaxoSmithKline.

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System Requirements:

is required for proper viewing. Click here to download Pentium 500 processor or greater Windows 98/NT/2000/XP or Mac OS 9/X Microsoft Internet Explorer 5.5 or later (Firefox browser currently not supported) 128 MB of RAM Monitor settings: High color at 800 x 600 pixels Sound card and speakers Audio troubleshooting For general troubleshooting concerning audio or video playback issues consult the following Web link: http://support.microsoft.com/kb/306317.